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KMID : 1030220140150040216
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Journal of Korean Diabetes
2014 Volume.15 No. 4 p.216 ~ p.220
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Circadian Rhythm Disruption and Metabolic Syndrome
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Kim Da-Ham
Jo Young-Suk
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Abstract
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Metabolic syndrome is a complex disorder and an emerging clinical challenge. It is induced by the interplay of genetic and environmental factors. Recently, evidence has emerged to suggest that circadian rhythm disruption is a new risk factor to explain the increased incidence of metabolic syndrome. This review summarizes circadian rhythm biology and the evidence linking circadian rhythm disruptions to metabolic syndrome, as related to lipid metabolism, glucose homeostasis, and cardiovascular function. Further understanding of circadian rhythm will aid the development of novel therapeutic strategies for metabolic syndrome.
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KEYWORD
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Circadian rhythm, Metabolic syndrome, Obesity, Diabetes mellitus, Cardiovascular disease
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